Immanuel Kant wrote that all our questions of human reason and speculation combine into three questions: “What can I know? What ought I to do? What may I hope?

The philosopher Immanuel Kant wrote that all our questions of human reason and speculation combine into three questions: “What can I know?  What ought I to do?  What may I hope?”  (Critique of Pure Reason, 1787)

From your perspective, as an individual living in the 21st century, are these three questions relevant for today?  Why or why not?